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Correlated Evolution of Positions within Mammalian cis Elements

Transcriptional regulation critically depends on proper interactions between transcription factors (TF) and their cognate DNA binding sites. The widely used model of TF-DNA binding – the Positional Weight Matrix (PWM) – presumes independence between positions within the binding site. However, there...

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Detalles Bibliográficos
Autores principales: Mukherjee, Rithun, Evans, Perry, Singh, Larry N., Hannenhalli, Sridhar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568137/
https://www.ncbi.nlm.nih.gov/pubmed/23408994
http://dx.doi.org/10.1371/journal.pone.0055521