Protein Arginine Methylation Is More Prone to Inhibition by S-Adenosylhomocysteine than DNA Methylation in Vascular Endothelial Cells

Methyltransferases use S-adenosylmethionine (AdoMet) as methyl group donor, forming S-adenosylhomocysteine (AdoHcy) and methylated substrates, including DNA and proteins. AdoHcy inhibits most methyltransferases. Accumulation of intracellular AdoHcy secondary to Hcy elevation elicits global DNA hypom...

Descripción completa

Detalles Bibliográficos
Autores principales: Esse, Ruben, Rocha, Monica S., Barroso, Madalena, Florindo, Cristina, Teerlink, Tom, Kok, Robert M., Smulders, Yvo M., Rivera, Isabel, Leandro, Paula, Koolwijk, Pieter, Castro, Rita, Blom, Henk J., de Almeida, Isabel Tavares
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568140/
https://www.ncbi.nlm.nih.gov/pubmed/23408989
http://dx.doi.org/10.1371/journal.pone.0055483

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568140/
https://www.ncbi.nlm.nih.gov/pubmed/23408989
http://dx.doi.org/10.1371/journal.pone.0055483

Ejemplares similares