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The role of conformational flexibility in β(2)-microglobulin amyloid fibril formation at neutral pH
RATIONALE Amyloid formation is implicated in a number of human diseases. β(2)-microglobulin (β(2)m) is the precursor protein in dialysis-related amyloidosis and it has been shown that partial, or more complete, unfolding is key to amyloid fibril formation in this pathology. Here the relationship bet...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Blackwell Publishing Ltd
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568905/ https://www.ncbi.nlm.nih.gov/pubmed/22777780 http://dx.doi.org/10.1002/rcm.6282 |