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The role of conformational flexibility in β(2)-microglobulin amyloid fibril formation at neutral pH

RATIONALE Amyloid formation is implicated in a number of human diseases. β(2)-microglobulin (β(2)m) is the precursor protein in dialysis-related amyloidosis and it has been shown that partial, or more complete, unfolding is key to amyloid fibril formation in this pathology. Here the relationship bet...

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Detalles Bibliográficos
Autores principales:	Hodkinson, John P, Radford, Sheena E, Ashcroft, Alison E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2012
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568905/ https://www.ncbi.nlm.nih.gov/pubmed/22777780 http://dx.doi.org/10.1002/rcm.6282

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