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Spike-Driven Glutamate Electrodiffusion Triggers Synaptic Potentiation via a Homer-Dependent mGluR-NMDAR Link

Electric fields of synaptic currents can influence diffusion of charged neurotransmitters, such as glutamate, in the synaptic cleft. However, this phenomenon has hitherto been detected only through sustained depolarization of large principal neurons, and its adaptive significance remains unknown. He...

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Detalles Bibliográficos
Autores principales: Sylantyev, Sergiy, Savtchenko, Leonid P., Ermolyuk, Yaroslav, Michaluk, Piotr, Rusakov, Dmitri A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568920/
https://www.ncbi.nlm.nih.gov/pubmed/23395378
http://dx.doi.org/10.1016/j.neuron.2012.11.026