Cargando…
Tumor-specific CD4(+) T cells develop cytotoxic activity and eliminate virus-induced tumor cells in the absence of regulatory T cells
The important role of tumor-specific cytotoxic CD8(+) T cells is well defined in the immune control of the tumors, but the role of effector CD4(+) T cells is poorly understood. In the current research, we have used a murine retrovirus-induced tumor cell line of C57BL/6 mouse origin, namely FBL-3 cel...
Autores principales: | Akhmetzyanova, Ilseyar, Zelinskyy, Gennadiy, Schimmer, Simone, Brandau, Sven, Altenhoff, Petra, Sparwasser, Tim, Dittmer, Ulf |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569596/ https://www.ncbi.nlm.nih.gov/pubmed/22890822 http://dx.doi.org/10.1007/s00262-012-1329-y |
Ejemplares similares
-
Regulatory T Cells Suppress Antiviral Immune Responses and Increase Viral Loads during Acute Infection with a Lymphotropic Retrovirus
por: Zelinskyy, Gennadiy, et al.
Publicado: (2009) -
Natural regulatory T cells inhibit production of cytotoxic molecules in CD8(+) T cells during low-level Friend retrovirus infection
por: Zelinskyy, Gennadiy, et al.
Publicado: (2013) -
Combining Regulatory T Cell Depletion and Inhibitory Receptor Blockade Improves Reactivation of Exhausted Virus-Specific CD8(+) T Cells and Efficiently Reduces Chronic Retroviral Loads
por: Dietze, Kirsten K., et al.
Publicado: (2013) -
Activated regulatory T cells suppress effector NK cell responses by an IL-2-mediated mechanism during an acute retroviral infection
por: Littwitz-Salomon, Elisabeth, et al.
Publicado: (2015) -
PD-L1 Expression on Retrovirus-Infected Cells Mediates Immune Escape from CD8(+) T Cell Killing
por: Akhmetzyanova, Ilseyar, et al.
Publicado: (2015)