Sustained expression of the transcription factor GLIS3 is required for normal beta cell function in adults

Genome-wide association studies identified GLIS3 as a susceptibility locus for type 1 and type 2 diabetes. Global Glis3 deficiency in mice leads to congenital diabetes and neonatal lethality. In this study, we explore the role of Glis3 in adulthood using Glis3(+/−) and conditional knockout animals....

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Detalles Bibliográficos
Autores principales: Yang, Yisheng, Chang, Benny Hung-Junn, Chan, Lawrence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569656/
https://www.ncbi.nlm.nih.gov/pubmed/23197416
http://dx.doi.org/10.1002/emmm.201201398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569656/
https://www.ncbi.nlm.nih.gov/pubmed/23197416
http://dx.doi.org/10.1002/emmm.201201398

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