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Sustained expression of the transcription factor GLIS3 is required for normal beta cell function in adults
Genome-wide association studies identified GLIS3 as a susceptibility locus for type 1 and type 2 diabetes. Global Glis3 deficiency in mice leads to congenital diabetes and neonatal lethality. In this study, we explore the role of Glis3 in adulthood using Glis3(+/−) and conditional knockout animals....
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
WILEY-VCH Verlag
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569656/ https://www.ncbi.nlm.nih.gov/pubmed/23197416 http://dx.doi.org/10.1002/emmm.201201398 |