Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies

Many human monoclonal antibodies that neutralize multiple clades of HIV-1 are polyreactive and bind avidly to mammalian autoantigens. Indeed, the generation of neutralizing antibodies to the 2F5 and 4E10 epitopes of HIV-1 gp41 in man may be proscribed by immune tolerance because mice expressing the...

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Detalles Bibliográficos
Autores principales: Yang, Guang, Holl, T. Matt, Liu, Yang, Li, Yi, Lu, Xiaozhi, Nicely, Nathan I., Kepler, Thomas B., Alam, S. Munir, Liao, Hua-Xin, Cain, Derek W., Spicer, Leonard, VandeBerg, John L., Haynes, Barton F., Kelsoe, Garnett
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570098/
https://www.ncbi.nlm.nih.gov/pubmed/23359068
http://dx.doi.org/10.1084/jem.20121977

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570098/
https://www.ncbi.nlm.nih.gov/pubmed/23359068
http://dx.doi.org/10.1084/jem.20121977

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