Notch activation inhibits AML growth and survival: a potential therapeutic approach

Although aberrant Notch activation contributes to leukemogenesis in T cells, its role in acute myelogenous leukemia (AML) remains unclear. Here, we report that human AML samples have robust expression of Notch receptors; however, Notch receptor activation and expression of downstream Notch targets a...

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Detalles Bibliográficos
Autores principales: Kannan, Sankaranarayanan, Sutphin, Robert M., Hall, Mandy G., Golfman, Leonard S., Fang, Wendy, Nolo, Riitta M., Akers, Lauren J., Hammitt, Richard A., McMurray, John S., Kornblau, Steven M., Melnick, Ari M., Figueroa, Maria E., Zweidler-McKay, Patrick A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570106/
https://www.ncbi.nlm.nih.gov/pubmed/23359069
http://dx.doi.org/10.1084/jem.20121527

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570106/
https://www.ncbi.nlm.nih.gov/pubmed/23359069
http://dx.doi.org/10.1084/jem.20121527

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