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Characterization of fast-decaying PET radiotracers solely through LC-MS/MS of constituent radioactive and carrier isotopologues

BACKGROUND: The characterization of fast-decaying radiotracers that are labeled with carbon-11 (t(1/2) = 20.38 min), including critical measurement of specific radioactivity (activity per mole at a specific time) before release for use in positron-emission tomography (PET), has relied heavily on chr...

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Detalles Bibliográficos
Autores principales: Shetty, H Umesha, Morse, Cheryl L, Zhang, Yi, Pike, Victor W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570351/
https://www.ncbi.nlm.nih.gov/pubmed/23311872
http://dx.doi.org/10.1186/2191-219X-3-3