Betulinic Acid Selectively Increases Protein Degradation and Enhances Prostate Cancer-Specific Apoptosis: Possible Role for Inhibition of Deubiquitinase Activity

Inhibition of the ubiquitin-proteasome system (UPS) of protein degradation is a valid anti-cancer strategy and has led to the approval of bortezomib for the treatment of multiple myeloma. However, the alternative approach of enhancing the degradation of oncoproteins that are frequently overexpressed...

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Detalles Bibliográficos
Autores principales: Reiner, Teresita, Parrondo, Ricardo, de las Pozas, Alicia, Palenzuela, Deanna, Perez-Stable, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570422/
https://www.ncbi.nlm.nih.gov/pubmed/23424652
http://dx.doi.org/10.1371/journal.pone.0056234

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570422/
https://www.ncbi.nlm.nih.gov/pubmed/23424652
http://dx.doi.org/10.1371/journal.pone.0056234

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