Akt and c-Myc Induce Stem-Cell Markers in Mature Primary p53(−/−) Astrocytes and Render These Cells Gliomagenic in the Brain of Immunocompetent Mice

Astrocytomas and their most malignant variant glioblastoma multiforme (GBM) represent the vast majority of primary brain tumors. Despite the current progress in neurosurgery, radiation therapy and chemotherapy, most astrocytomas remain fatal disorders. Although brain tumor biology is a matter of int...

Descripción completa

Detalles Bibliográficos
Autores principales: Radke, Josefine, Bortolussi, Ginette, Pagenstecher, Axel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570527/
https://www.ncbi.nlm.nih.gov/pubmed/23424671
http://dx.doi.org/10.1371/journal.pone.0056691

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570527/
https://www.ncbi.nlm.nih.gov/pubmed/23424671
http://dx.doi.org/10.1371/journal.pone.0056691

Ejemplares similares