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Akt and c-Myc Induce Stem-Cell Markers in Mature Primary p53(−/−) Astrocytes and Render These Cells Gliomagenic in the Brain of Immunocompetent Mice
Astrocytomas and their most malignant variant glioblastoma multiforme (GBM) represent the vast majority of primary brain tumors. Despite the current progress in neurosurgery, radiation therapy and chemotherapy, most astrocytomas remain fatal disorders. Although brain tumor biology is a matter of int...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570527/ https://www.ncbi.nlm.nih.gov/pubmed/23424671 http://dx.doi.org/10.1371/journal.pone.0056691 |