CD134/CD137 Dual Costimulation-Elicited IFN-γ Maximizes Effector T Cell Function but Limits Treg Expansion

T cell tolerance to tumor antigens represents a major hurdle in generating tumor immunity. Combined administration of agonistic monoclonal antibodies to the costimulatory receptors CD134 plus CD137 can program T cells responding to tolerogenic antigen to undergo expansion and effector T cell differe...

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Detalles Bibliográficos
Autores principales: Rose, Marie-Clare St., Taylor, Roslyn A., Bandyopadhyay, Suman, Qui, Harry Z., Hagymasi, Adam T., Vella, Anthony T., Adler, Adam J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570742/
https://www.ncbi.nlm.nih.gov/pubmed/23295363
http://dx.doi.org/10.1038/icb.2012.74

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570742/
https://www.ncbi.nlm.nih.gov/pubmed/23295363
http://dx.doi.org/10.1038/icb.2012.74

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