Cargando…

CD134/CD137 Dual Costimulation-Elicited IFN-γ Maximizes Effector T Cell Function but Limits Treg Expansion

T cell tolerance to tumor antigens represents a major hurdle in generating tumor immunity. Combined administration of agonistic monoclonal antibodies to the costimulatory receptors CD134 plus CD137 can program T cells responding to tolerogenic antigen to undergo expansion and effector T cell differe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rose, Marie-Clare St., Taylor, Roslyn A., Bandyopadhyay, Suman, Qui, Harry Z., Hagymasi, Adam T., Vella, Anthony T., Adler, Adam J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570742/ https://www.ncbi.nlm.nih.gov/pubmed/23295363 http://dx.doi.org/10.1038/icb.2012.74

Ejemplares similares

A mathematical model of combined CD8 T cell costimulation by 4-1BB (CD137) and OX40 (CD134) receptors
por: Konstorum, Anna, et al.
Publicado: (2019)

Betting on improved cancer immunotherapy by doubling down on CD134 and CD137 co-stimulation
por: Adler, Adam J., et al.
Publicado: (2013)

Hypoxia-induced soluble CD137 in malignant cells blocks CD137L-costimulation as an immune escape mechanism
por: Labiano, Sara, et al.
Publicado: (2014)

Chronic CD27-CD70 costimulation promotes type 1-specific polarization of effector Tregs
por: Bowakim-Anta, Natalia, et al.
Publicado: (2023)

Evaluating the glycolytic potential of mouse costimulated effector CD8(+) T cells ex vivo
por: Agliano, Federica, et al.
Publicado: (2022)

Immunogenicity risk assessment for biotherapeutics through in vitro detection of CD134 and CD137 on T helper cells
por: Cohen, Sivan, et al.
Publicado: (2021)

CD137-CD137 Ligand Interactions in Inflammation
por: Kwon, Byungsuk
Publicado: (2009)

CD137 (4-1BB) costimulation of CD8(+) T cells is more potent when provided in cis than in trans with respect to CD3-TCR stimulation
por: Otano, Itziar, et al.
Publicado: (2021)

Costimulation blockade and Tregs in solid organ transplantation
por: Muckenhuber, Moritz, et al.
Publicado: (2022)

CD28, Costimulator or Agonist Receptor?
por: Margulies, David H.
Publicado: (2003)

CD137 costimulation enhances the antiviral activity of Vγ9Vδ2-T cells against influenza virus
por: Pei, Yujun, et al.
Publicado: (2020)

Optimal CD8(+) T cell effector function requires costimulation-induced RNA-binding proteins that reprogram the transcript isoform landscape
por: Karginov, Timofey A., et al.
Publicado: (2022)

CD137+CD154− Expression As a Regulatory T Cell (Treg)-Specific Activation Signature for Identification and Sorting of Stable Human Tregs from In Vitro Expansion Cultures
por: Nowak, Anna, et al.
Publicado: (2018)

Two pathways of costimulation through CD28
por: Miller, Jim, et al.
Publicado: (2009)

A pathway of costimulation that prevents anergy in CD28- T cells: B7- independent costimulation of CD1-restricted T cells
Publicado: (1995)

Feasibility of up-regulating CD4(+)CD25(+) Tregs by IFN-γ in myasthenia gravis patients
por: Huang, Shuo, et al.
Publicado: (2015)

Soluble CD137 as a dynamic biomarker to monitor agonist CD137 immunotherapies
por: Glez-Vaz, Javier, et al.
Publicado: (2022)

CD80 Costimulation Is Essential for the Induction of Airway Eosinophilia
por: Harris, Nicola, et al.
Publicado: (1997)

Is CD137 Ligand (CD137L) Signaling a Fine Tuner of Immune Responses?
por: Kwon, Byungsuk
Publicado: (2015)

Correction: Soluble CD137 as a dynamic biomarker to monitor agonist CD137 immunotherapies
Publicado: (2023)

CD137 Costimulation Enhances the Antitumor Activity of Vγ9Vδ2-T Cells in IL-10-Mediated Immunosuppressive Tumor Microenvironment
por: Pei, Yujun, et al.
Publicado: (2022)

Increased Soluble CD137 Levels and CD4+ T‐Cell‐Associated Expression of CD137 in Acute Atherothrombotic Stroke
por: He, Yang, et al.
Publicado: (2018)

CD28 Costimulation Is Required for In Vivo Induction of Peripheral Tolerance in CD8 T Cells
por: Vacchio, Melanie S., et al.
Publicado: (2003)

Chronic Inflammation Increases the Sensitivity of Mouse Treg for TNFR2 Costimulation
por: Schmid, Tobias, et al.
Publicado: (2017)

SA-4-1BBL Costimulation Inhibits Conversion of Conventional CD4(+) T Cells into CD4(+)FoxP3(+) T Regulatory Cells by Production of IFN-γ
por: Madireddi, Shravan, et al.
Publicado: (2012)

Regulatory T Cells Inhibit T Cell Activity by Downregulating CD137 Ligand via CD137 Trogocytosis
por: Luu, Khang, et al.
Publicado: (2021)

The Murine CD137/CD137 Ligand Signalosome: A Signal Platform Generating Signal Complexity
por: Choi, Beom K., et al.
Publicado: (2020)

Costimulation to enhance the antitumor activity of CD19 eng T cells
por: Velasquez, Mireya, et al.
Publicado: (2015)

Sialic Acid Ligands of CD28 Suppress Costimulation of T Cells
por: Edgar, Landon J., et al.
Publicado: (2021)

A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade
por: Geuijen, Cecile, et al.
Publicado: (2021)

The Roles of CD137 Signaling in Atherosclerosis
por: Jung, In-Hyuk, et al.
Publicado: (2016)

Correction: SA-4-1BBL Costimulation Inhibits Conversion of Conventional CD4(+) T Cells into CD4(+)FoxP3(+) T Regulatory Cells by Production of IFN-γ
por: Madireddi, Shravan, et al.
Publicado: (2012)

The Progress of Investigating the CD137-CD137L Axis as a Potential Target for Systemic Lupus Erythematosus
por: Mak, Anselm, et al.
Publicado: (2019)

In Vivo Dynamical Interactions between CD4 Tregs, CD8 Tregs and CD4(+)CD25(−) Cells in Mice
por: Arazi, Arnon, et al.
Publicado: (2009)

Circulating CD4(+) Treg, CD8(+) Treg, and CD3(+) γδ T Cell Subpopulations in Ovarian Cancer
por: Li, Rong, et al.
Publicado: (2023)

Itk Negatively Regulates Induction of T Cell Proliferation by CD28 Costimulation
por: Liao, X. Charlene, et al.
Publicado: (1997)

CD28 Costimulation Regulates Genome-Wide Effects on Alternative Splicing
por: Butte, Manish J., et al.
Publicado: (2012)

Characterization of the human T cell response to in vitro CD27 costimulation with varlilumab
por: Ramakrishna, Venky, et al.
Publicado: (2015)

Membrane Rafts in T Cell Activation: A Spotlight on CD28 Costimulation
por: Zumerle, Sara, et al.
Publicado: (2017)

CD81 costimulation skews CAR transduction toward naive T cells
por: Schultz, Liora M., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_tl545l5qe1ng4gtso9rrbbgil2