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Non-catalytic participation of the Pin1 peptidyl-prolyl isomerase domain in target binding

Pin1 is a phosphorylation-dependent peptidyl-prolyl isomerase (PPIase) that has the potential to add an additional level of regulation within protein kinase mediated signaling pathways. Furthermore, there is a mounting body of evidence implicating Pin1 in the emergence of pathological phenotypes in...

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Detalles Bibliográficos
Autores principales: Innes, Brendan T., Bailey, Melanie L., Brandl, Christopher J., Shilton, Brian H., Litchfield, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3571201/
https://www.ncbi.nlm.nih.gov/pubmed/23407864
http://dx.doi.org/10.3389/fphys.2013.00018