Preventing the transmission of pathogenic mitochondrial DNA mutations: can we achieve long-term benefits from germ-line gene transfer?

Mitochondrial medicine is one of the few areas of genetic disease where germ-line transfer is being actively pursued as a treatment option. All of the germ-line transfer methods currently under development involve some carry-over of the maternal mitochondrial DNA (mtDNA) heteroplasmy, potentially de...

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Detalles Bibliográficos
Autores principales: Samuels, David C., Wonnapinij, Passorn, Chinnery, Patrick F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3571501/
https://www.ncbi.nlm.nih.gov/pubmed/23297368
http://dx.doi.org/10.1093/humrep/des439

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3571501/
https://www.ncbi.nlm.nih.gov/pubmed/23297368
http://dx.doi.org/10.1093/humrep/des439

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