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Mammalian TIMELESS Is Involved in Period Determination and DNA Damage-Dependent Phase Advancing of the Circadian Clock

The transcription/translation feedback loop-based molecular oscillator underlying the generation of circadian gene expression is preserved in almost all organisms. Interestingly, the animal circadian clock proteins CRYPTOCHROME (CRY), PERIOD (PER) and TIMELESS (TIM) are strongly conserved at the ami...

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Detalles Bibliográficos
Autores principales: Engelen, Erik, Janssens, Roel C., Yagita, Kazuhiro, Smits, Veronique A. J., van der Horst, Gijsbertus T. J., Tamanini, Filippo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572085/
https://www.ncbi.nlm.nih.gov/pubmed/23418588
http://dx.doi.org/10.1371/journal.pone.0056623