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Prediction of P53 Mutants (Multiple Sites) Transcriptional Activity Based on Structural (2D&3D) Properties

Prediction of secondary site mutations that reinstate mutated p53 to normalcy has been the focus of intense research in the recent past owing to the fact that p53 mutants have been implicated in more than half of all human cancers and restoration of p53 causes tumor regression. However laboratory in...

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Detalles Bibliográficos
Autores principales: Geetha Ramani, R., Jacob, Shomona Gracia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572112/
https://www.ncbi.nlm.nih.gov/pubmed/23468845
http://dx.doi.org/10.1371/journal.pone.0055401