Cargando…

Pathogenic Mutation in VPS35 Impairs Its Protection against MPP(+) Cytotoxicity

Parkinson's disease primarily results from progressive degeneration of dopaminergic neurons in the substantia nigra. Both neuronal toxicants and genetic factors are suggested to be involved in the disease pathogenesis. The mitochondrial toxicant 1-methyl-4-phenylpyridinium (MPP(+)) shows a high...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bi, Fangfang, Li, Fang, Huang, Cao, Zhou, Hongxia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2013
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572397/ https://www.ncbi.nlm.nih.gov/pubmed/23411763 http://dx.doi.org/10.7150/ijbs.5617

Ejemplares similares

In vivo evidence of pathogenicity of VPS35 mutations in the Drosophila
por: Wang, Hua-shan, et al.
Publicado: (2014)

VPS35 Parkinson mutation impairs autophagy via WASH
por: Zavodszky, Eszter, et al.
Publicado: (2014)

Screening for VPS35 mutations in Parkinson's disease
por: Sheerin, Una-Marie, et al.
Publicado: (2012)

VPS35 depletion does not impair presynaptic structure and function
por: Vazquez-Sanchez, Sonia, et al.
Publicado: (2018)

Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagy
por: Zavodszky, Eszter, et al.
Publicado: (2014)

The protective effect of lactoferrin on ventral mesencephalon neurons against MPP(+) is not connected with its iron binding ability
por: Wang, Jun, et al.
Publicado: (2015)

Bacopa Protects against Neurotoxicity Induced by MPP(+) and Methamphetamine
por: Ferrucci, Michela, et al.
Publicado: (2022)

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration
por: Tsika, Elpida, et al.
Publicado: (2014)

VPS35 pathogenic mutations confer no dominant toxicity but partial loss of function in Drosophila and genetically interact with parkin
por: Malik, Bilal R., et al.
Publicado: (2015)

Retromer subunit, CfVps35 is required for growth development and pathogenicity of Colletotrichum fructicola
por: Li, Xi-Ya, et al.
Publicado: (2022)

VPS35 leaves endosomes lost in transition
por: Leslie, Mitch
Publicado: (2011)

VPS35, the Retromer Complex and Parkinson’s Disease
por: Williams, Erin T., et al.
Publicado: (2017)

Conditioned Medium of Human Menstrual Blood-Derived Endometrial Stem Cells Protects Against MPP(+)-Induced Cytotoxicity in vitro
por: Li, Han, et al.
Publicado: (2019)

Endosome to Golgi Retrieval of the Vacuolar Protein Sorting Receptor, Vps10p, Requires the Function of the VPS29, VPS30, and VPS35 Gene Products
por: Seaman, Matthew N.J., et al.
Publicado: (1997)

VPS35 haploinsufficiency increases Alzheimer’s disease neuropathology
por: Wen, Lei, et al.
Publicado: (2011)

VPS35 regulates tau phosphorylation and neuropathology in tauopathy
por: Vagnozzi, Alana N., et al.
Publicado: (2021)

VPS35-deficiency results in an impaired AMPA receptor trafficking and decreased dendritic spine maturation
por: Tian, Yun, et al.
Publicado: (2015)

Vps35-deficiency impairs SLC4A11 trafficking and promotes corneal dystrophy
por: Liu, Wei, et al.
Publicado: (2017)

Mitochondrial and Clearance Impairment in p.D620N VPS35 Patient‐Derived Neurons
por: Hanss, Zoé, et al.
Publicado: (2020)

Vps35 Deficiency Impairs Cdk5/p35 Degradation and Promotes the Hyperphosphorylation of Tau Protein in Retinal Ganglion Cells
por: Gao, Ling, et al.
Publicado: (2020)

MPP(+)-induced cytotoxicity in neuroblastoma cells: Antagonism and reversal by guanosine
por: Pettifer, Kathleen M., et al.
Publicado: (2007)

Paeonolum protects against MPP(+)-induced neurotoxicity in zebrafish and PC12 cells
por: Lu, Xi-Lin, et al.
Publicado: (2015)

VPS35, the core component of the retromer complex, and Parkinson's disease
por: Luo, Ai‐Di, et al.
Publicado: (2021)

Elevated urine BMP phospholipids in LRRK2 and VPS35 mutation carriers with and without Parkinson’s disease
por: Gomes, Sara, et al.
Publicado: (2023)

Protective effects of Cervus nippon Temminck velvet antler polypeptides against MPP(+)-induced cytotoxicity in SH-SY5Y neuroblastoma cells
por: Xin, Ji-Le, et al.
Publicado: (2017)

The Alteration of Nasopharyngeal and Oropharyngeal Microbiota in Children with MPP and Non-MPP
por: Lu, Zhiwei, et al.
Publicado: (2017)

Mutations in GBA, SNCA, and VPS35 are not associated with Alzheimer’s disease in a Chinese population: a case-control study
por: Wen, Ya-Fei, et al.
Publicado: (2021)

Parkinson’s Disease Causative Mutation in Vps35 Disturbs Tetherin Trafficking to Cell Surfaces and Facilitates Virus Spread
por: Ding, Yingzhuo, et al.
Publicado: (2021)

Salidroside Protects against MPP+-Induced Neuronal Injury through DJ-1-Nrf2 Antioxidant Pathway
por: Wu, Leitao, et al.
Publicado: (2017)

Mild MPP(+) exposure-induced glucose starvation enhances autophagosome synthesis and impairs its degradation
por: Sakamoto, Shuichiro, et al.
Publicado: (2017)

Vps35 loss promotes hyperresorptive osteoclastogenesis and osteoporosis via sustained RANKL signaling
por: Xia, Wen-Fang, et al.
Publicado: (2013)

Expression of Low Level of VPS35-mCherry Fusion Protein Diminishes Vps35 Depletion Induced Neuron Terminal Differentiation Deficits and Neurodegenerative Pathology, and Prevents Neonatal Death
por: Zhao, Yang, et al.
Publicado: (2021)

2013 MPP Workshop
por: Jonker, Michael
Publicado: (2014)

Protective Effects of SKF-96365, a Non-Specific Inhibitor of SOCE, against MPP(+)-Induced Cytotoxicity in PC12 Cells: Potential Role of Homer1
por: Chen, Tao, et al.
Publicado: (2013)

Potential protective effects of autophagy activated in MPP+ treated astrocytes
por: Shen, Cunzhou, et al.
Publicado: (2016)

Mitochondrial Uncoupling Protein-2 (UCP2) Mediates Leptin Protection Against MPP(+) Toxicity in Neuronal Cells
por: Ho, Philip Wing-Lok, et al.
Publicado: (2009)

VPS35-Based Approach: A Potential Innovative Treatment in Parkinson's Disease
por: Eleuteri, Simona, et al.
Publicado: (2019)

Mitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA
por: Sen, Ayesha, et al.
Publicado: (2022)

Novel pathogenic VPS13A gene mutations in Japanese patients with chorea-acanthocytosis
por: Nishida, Yoshiaki, et al.
Publicado: (2019)

Parkinson’s disease–associated VPS35 mutant reduces mitochondrial membrane potential and impairs PINK1/Parkin-mediated mitophagy
por: Ma, Kai Yu, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_qih6b62hkmagdj0cufb1rfte6i