Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6

Tenovin-6 (Tnv-6) is a bioactive small molecule with anti-neoplastic activity. Inhibition of the Sirtuin class of protein deacetylases with activation of p53 function is associated with the pro-apoptotic effects of Tnv-6 in many tumors. Here, we demonstrate that in chronic lymphocytic leukemia (CLL)...

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Detalles Bibliográficos
Autores principales: MacCallum, Stephanie F., Groves, Michael J., James, John, Murray, Karen, Appleyard, Virginia, Prescott, Alan R., Drbal, Abed A., Nicolaou, Anna, Cunningham, Joan, Haydock, Sally, Ganley, Ian G., Westwood, Nicholas J., Coates, Philip J., Lain, Sonia, Tauro, Sudhir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572444/
https://www.ncbi.nlm.nih.gov/pubmed/23429453
http://dx.doi.org/10.1038/srep01275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572444/
https://www.ncbi.nlm.nih.gov/pubmed/23429453
http://dx.doi.org/10.1038/srep01275

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