Dopamine signaling negatively regulates striatal phosphorylation of Cdk5 at tyrosine 15 in mice

Striatal functions depend on the activity balance between the dopamine and glutamate neurotransmissions. Glutamate inputs activate cyclin-dependent kinase 5 (Cdk5), which inhibits postsynaptic dopamine signaling by phosphorylating DARPP-32 (dopamine- and cAMP-regulated phosphoprotein, 32 kDa) at Thr...

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Detalles Bibliográficos
Autores principales: Yamamura, Yukio, Morigaki, Ryoma, Kasahara, Jiro, Yokoyama, Hironori, Tanabe, Akie, Okita, Shinya, Koizumi, Hidetaka, Nagahiro, Shinji, Kaji, Ryuji, Goto, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572678/
https://www.ncbi.nlm.nih.gov/pubmed/23420105
http://dx.doi.org/10.3389/fncel.2013.00012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572678/
https://www.ncbi.nlm.nih.gov/pubmed/23420105
http://dx.doi.org/10.3389/fncel.2013.00012

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