DNA Prime/Adenovirus Boost Malaria Vaccine Encoding P. falciparum CSP and AMA1 Induces Sterile Protection Associated with Cell-Mediated Immunity

BACKGROUND: Gene-based vaccination using prime/boost regimens protects animals and humans against malaria, inducing cell-mediated responses that in animal models target liver stage malaria parasites. We tested a DNA prime/adenovirus boost malaria vaccine in a Phase 1 clinical trial with controlled h...

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Detalles Bibliográficos
Autores principales: Chuang, Ilin, Sedegah, Martha, Cicatelli, Susan, Spring, Michele, Polhemus, Mark, Tamminga, Cindy, Patterson, Noelle, Guerrero, Melanie, Bennett, Jason W., McGrath, Shannon, Ganeshan, Harini, Belmonte, Maria, Farooq, Fouzia, Abot, Esteban, Banania, Jo Glenna, Huang, Jun, Newcomer, Rhonda, Rein, Lisa, Litilit, Dianne, Richie, Nancy O., Wood, Chloe, Murphy, Jittawadee, Sauerwein, Robert, Hermsen, Cornelus C., McCoy, Andrea J., Kamau, Edwin, Cummings, James, Komisar, Jack, Sutamihardja, Awalludin, Shi, Meng, Epstein, Judith E., Maiolatesi, Santina, Tosh, Donna, Limbach, Keith, Angov, Evelina, Bergmann-Leitner, Elke, Bruder, Joseph T., Doolan, Denise L., King, C. Richter, Carucci, Daniel, Dutta, Sheetij, Soisson, Lorraine, Diggs, Carter, Hollingdale, Michael R., Ockenhouse, Christian F., Richie, Thomas L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573028/
https://www.ncbi.nlm.nih.gov/pubmed/23457473
http://dx.doi.org/10.1371/journal.pone.0055571

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573028/
https://www.ncbi.nlm.nih.gov/pubmed/23457473
http://dx.doi.org/10.1371/journal.pone.0055571

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