Allosteric Regulation of Serine Protease HtrA2 through Novel Non-Canonical Substrate Binding Pocket

HtrA2, a trimeric proapoptotic serine protease is involved in several diseases including cancer and neurodegenerative disorders. Its unique ability to mediate apoptosis via multiple pathways makes it an important therapeutic target. In HtrA2, C-terminal PDZ domain upon substrate binding regulates it...

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Detalles Bibliográficos
Autores principales: Bejugam, Pruthvi Raj, Kuppili, Raja R., Singh, Nitu, Gadewal, Nikhil, Chaganti, Lalith K., Sastry, G. Madhavi, Bose, Kakoli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573033/
https://www.ncbi.nlm.nih.gov/pubmed/23457469
http://dx.doi.org/10.1371/journal.pone.0055416

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573033/
https://www.ncbi.nlm.nih.gov/pubmed/23457469
http://dx.doi.org/10.1371/journal.pone.0055416

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