A Kinome-Wide RNAi Screen in Drosophila Glia Reveals That the RIO Kinases Mediate Cell Proliferation and Survival through TORC2-Akt Signaling in Glioblastoma

Glioblastoma, the most common primary malignant brain tumor, is incurable with current therapies. Genetic and molecular analyses demonstrate that glioblastomas frequently display mutations that activate receptor tyrosine kinase (RTK) and Pi-3 kinase (PI3K) signaling pathways. In Drosophila melanogas...

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Detalles Bibliográficos
Autores principales: Read, Renee D., Fenton, Tim R., Gomez, German G., Wykosky, Jill, Vandenberg, Scott R., Babic, Ivan, Iwanami, Akio, Yang, Huijun, Cavenee, Webster K., Mischel, Paul S., Furnari, Frank B., Thomas, John B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573097/
https://www.ncbi.nlm.nih.gov/pubmed/23459592
http://dx.doi.org/10.1371/journal.pgen.1003253

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573097/
https://www.ncbi.nlm.nih.gov/pubmed/23459592
http://dx.doi.org/10.1371/journal.pgen.1003253

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