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Influenza HA Subtypes Demonstrate Divergent Phenotypes for Cleavage Activation and pH of Fusion: Implications for Host Range and Adaptation

The influenza A virus (IAV) HA protein must be activated by host cells proteases in order to prime the molecule for fusion. Consequently, the availability of activating proteases and the susceptibility of HA to protease activity represents key factors in facilitating virus infection. As such, unders...

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Detalles Bibliográficos
Autores principales: Galloway, Summer E., Reed, Mark L., Russell, Charles J., Steinhauer, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573126/
https://www.ncbi.nlm.nih.gov/pubmed/23459660
http://dx.doi.org/10.1371/journal.ppat.1003151