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Oxidative stress, fibrosis, and early afterdepolarization-mediated cardiac arrhythmias

Animal and clinical studies have demonstrated that oxidative stress, a common pathophysiological factor in cardiac disease, reduces repolarization reserve by enhancing the L-type calcium current, the late Na, and the Na-Ca exchanger, promoting early afterdepolarizations (EADs) that can initiate vent...

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Detalles Bibliográficos
Autores principales: Karagueuzian, Hrayr S., Nguyen, Thao P., Qu, Zhilin, Weiss, James N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573324/
https://www.ncbi.nlm.nih.gov/pubmed/23423152
http://dx.doi.org/10.3389/fphys.2013.00019