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Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice
BACKGROUND: A hallmark of Alzheimer’s disease is the presence of senile plaques in human brain primarily containing the amyloid peptides Aβ(42) and Aβ(40). Many drug discovery efforts have focused on decreasing the production of Aβ(42) through γ-secretase inhibition. However, identification of γ-sec...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573960/ https://www.ncbi.nlm.nih.gov/pubmed/23249765 http://dx.doi.org/10.1186/1750-1326-7-61 |