Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice

BACKGROUND: A hallmark of Alzheimer’s disease is the presence of senile plaques in human brain primarily containing the amyloid peptides Aβ(42) and Aβ(40). Many drug discovery efforts have focused on decreasing the production of Aβ(42) through γ-secretase inhibition. However, identification of γ-sec...

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Detalles Bibliográficos
Autores principales: Rogers, Kathryn, Felsenstein, Kevin M, Hrdlicka, Lori, Tu, Zhiming, Albayya, Faris, Lee, Winnie, Hopp, Sarah, Miller, Mary-Jo, Spaulding, Darcie, Yang, Zhiyong, Hodgdon, Hilliary, Nolan, Scott, Wen, Melody, Costa, Don, Blain, Jean-Francois, Freeman, Emily, De Strooper, Bart, Vulsteke, Veerle, Scrocchi, Louise, Zetterberg, Henrik, Portelius, Erik, Hutter-Paier, Birgit, Havas, Daniel, Ahlijanian, Michael, Flood, Dorothy, Leventhal, Liza, Shapiro, Gideon, Patzke, Holger, Chesworth, Richard, Koenig, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573960/
https://www.ncbi.nlm.nih.gov/pubmed/23249765
http://dx.doi.org/10.1186/1750-1326-7-61

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