Xenogeneic Human p53 DNA Vaccination by Electroporation Breaks Immune Tolerance to Control Murine Tumors Expressing Mouse p53

The pivotal role of p53 as a tumor suppressor protein is illustrated by the fact that this protein is found mutated in more than 50% of human cancers. In most cases, mutations in p53 greatly increase the otherwise short half-life of this protein in normal tissue and cause it to accumulate in the cyt...

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Detalles Bibliográficos
Autores principales: Soong, Ruey-Shyang, Trieu, Janson, Lee, Sung Yong, He, Liangmei, Tsai, Ya-Chea, Wu, T.-C., Hung, Chien-Fu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574113/
https://www.ncbi.nlm.nih.gov/pubmed/23457640
http://dx.doi.org/10.1371/journal.pone.0056912

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574113/
https://www.ncbi.nlm.nih.gov/pubmed/23457640
http://dx.doi.org/10.1371/journal.pone.0056912

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