Deficiency in p38β MAPK Fails to Inhibit Cytokine Production or Protect Neurons against Inflammatory Insult in In Vitro and In Vivo Mouse Models

The p38 MAPK pathway plays a key role in regulating the production of proinflammatory cytokines, such as TNFα and IL-1β, in peripheral inflammatory disorders. There are four major isoforms of p38 MAPK (p38α, β, δ, γ), with p38α and p38β the targets of most p38 MAPK inhibitor drugs. Our previous stud...

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Detalles Bibliográficos
Autores principales: Xing, Bin, Bachstetter, Adam D., Van Eldik, Linda J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574114/
https://www.ncbi.nlm.nih.gov/pubmed/23457629
http://dx.doi.org/10.1371/journal.pone.0056852

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574114/
https://www.ncbi.nlm.nih.gov/pubmed/23457629
http://dx.doi.org/10.1371/journal.pone.0056852

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