CTLA-4 promotes Foxp3 induction and regulatory T cell accumulation in the intestinal lamina propria

Thymic induction of CD4(+)Foxp3(+) regulatory T (Treg) cells relies on CD28 costimulation and high-affinity T-cell receptor (TCR) signals, whereas Foxp3 (forkhead box P3) induction on activated peripheral CD4(+) T cells is inhibited by these signals. Accordingly, the inhibitory molecule CTLA-4 (cyto...

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Detalles Bibliográficos
Autores principales: Barnes, M J, Griseri, T, Johnson, A M F, Young, W, Powrie, F, Izcue, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574974/
https://www.ncbi.nlm.nih.gov/pubmed/22910217
http://dx.doi.org/10.1038/mi.2012.75

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574974/
https://www.ncbi.nlm.nih.gov/pubmed/22910217
http://dx.doi.org/10.1038/mi.2012.75

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