Pramanicin Analog Induces Apoptosis in Human Colon Cancer Cells: Critical Roles for Bcl-2, Bim, and p38 MAPK Signaling

Pramanicin (PMC) is an antifungal agent that was previously demonstrated to exhibit antiangiogenic and anticancer properties in a few in vitro studies. We initially screened a number of PMC analogs for their cytotoxic effects on HCT116 human colon cancer cells. PMC-A, the analog with the most potent...

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Detalles Bibliográficos
Autores principales: Bodur, Cagri, Kutuk, Ozgur, Karsli-Uzunbas, Gizem, Isimjan, Tayirjan T., Harrison, Paul, Basaga, Huveyda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575438/
https://www.ncbi.nlm.nih.gov/pubmed/23441183
http://dx.doi.org/10.1371/journal.pone.0056369

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575438/
https://www.ncbi.nlm.nih.gov/pubmed/23441183
http://dx.doi.org/10.1371/journal.pone.0056369

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