Engineering of a target site-specific recombinase by a combined evolution- and structure-guided approach

Site-specific recombinases (SSRs) can perform DNA rearrangements, including deletions, inversions and translocations when their naive target sequences are placed strategically into the genome of an organism. Hence, in order to employ SSRs in heterologous hosts, their target sites have to be introduc...

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Detalles Bibliográficos
Autores principales: Abi-Ghanem, Josephine, Chusainow, Janet, Karimova, Madina, Spiegel, Christopher, Hofmann-Sieber, Helga, Hauber, Joachim, Buchholz, Frank, Pisabarro, M. Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575804/
https://www.ncbi.nlm.nih.gov/pubmed/23275541
http://dx.doi.org/10.1093/nar/gks1308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575804/
https://www.ncbi.nlm.nih.gov/pubmed/23275541
http://dx.doi.org/10.1093/nar/gks1308

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