RAG and HMGB1 create a large bend in the 23RSS in the V(D)J recombination synaptic complexes

During V(D)J recombination, recombination activating gene proteins RAG1 and RAG2 generate DNA double strand breaks within a paired complex (PC) containing two complementary recombination signal sequences (RSSs), the 12RSS and 23RSS, which differ in the length of the spacer separating heptamer and no...

Descripción completa

Detalles Bibliográficos
Autores principales: Ciubotaru, Mihai, Trexler, Adam J., Spiridon, Laurentiu N., Surleac, Marius D., Rhoades, Elizabeth, Petrescu, Andrei J., Schatz, David G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575807/
https://www.ncbi.nlm.nih.gov/pubmed/23293004
http://dx.doi.org/10.1093/nar/gks1294

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575807/
https://www.ncbi.nlm.nih.gov/pubmed/23293004
http://dx.doi.org/10.1093/nar/gks1294

Ejemplares similares