Cargando…

RAG and HMGB1 create a large bend in the 23RSS in the V(D)J recombination synaptic complexes

During V(D)J recombination, recombination activating gene proteins RAG1 and RAG2 generate DNA double strand breaks within a paired complex (PC) containing two complementary recombination signal sequences (RSSs), the 12RSS and 23RSS, which differ in the length of the spacer separating heptamer and no...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ciubotaru, Mihai, Trexler, Adam J., Spiridon, Laurentiu N., Surleac, Marius D., Rhoades, Elizabeth, Petrescu, Andrei J., Schatz, David G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2013
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575807/ https://www.ncbi.nlm.nih.gov/pubmed/23293004 http://dx.doi.org/10.1093/nar/gks1294

Ejemplares similares

Cooperative recruitment of HMGB1 during V(D)J recombination through interactions with RAG1 and DNA
por: Little, Alicia J., et al.
Publicado: (2013)

The architecture of the 12RSS in V(D)J recombination signal and synaptic complexes
por: Ciubotaru, Mihai, et al.
Publicado: (2015)

Full-length RAG1 promotes contact with coding and intersignal sequences in RAG protein complexes bound to recombination signals paired in cis
por: Kumar, Sushil, et al.
Publicado: (2009)

Roles of the C-terminal domains of topoisomerase IIα and topoisomerase IIβ in regulation of the decatenation checkpoint
por: Kozuki, Toshiyuki, et al.
Publicado: (2017)

The role of DNA bending in type IIA topoisomerase function
por: Lee, Imsang, et al.
Publicado: (2013)

HMGB1 interacts with human topoisomerase IIα and stimulates its catalytic activity
por: Štros, Michal, et al.
Publicado: (2007)

DNA looping by FokI: the impact of twisting and bending rigidity on protein-induced looping dynamics
por: Laurens, Niels, et al.
Publicado: (2012)

The Mus81-Mms4 structure-selective endonuclease requires nicked DNA junctions to undergo conformational changes and bend its DNA substrates for cleavage
por: Mukherjee, Sucheta, et al.
Publicado: (2014)

Caught in the act: the lifetime of synaptic intermediates during the search for homology on DNA
por: Mani, Adam, et al.
Publicado: (2010)

T4 DNA ligase is more than an effective trap of cyclized dsDNA
por: Yuan, Chongli, et al.
Publicado: (2007)

Asymmetric positioning of Cas1–2 complex and Integration Host Factor induced DNA bending guide the unidirectional homing of protospacer in CRISPR-Cas type I-E system
por: Yoganand, K.N.R., et al.
Publicado: (2017)

Creating highly specific nucleases by fusion of active restriction endonucleases and catalytically inactive homing endonucleases
por: Fonfara, Ines, et al.
Publicado: (2012)

Hyperactive mariner transposons are created by mutations that disrupt allosterism and increase the rate of transposon end synapsis
por: Liu, Danxu, et al.
Publicado: (2014)

Endonuclease G preferentially cleaves 5-hydroxymethylcytosine-modified DNA creating a substrate for recombination
por: Robertson, Adam B., et al.
Publicado: (2014)

Creating a monomeric endonuclease TALE-I-SceI with high specificity and low genotoxicity in human cells
por: Lin, Jianfei, et al.
Publicado: (2015)

RIG-I recognizes metabolite-capped RNAs as signaling ligands
por: Schweibenz, Brandon D, et al.
Publicado: (2023)

Probing the stability of the SpCas9–DNA complex after cleavage
por: Aldag, Pierre, et al.
Publicado: (2021)

RNA Editing TUTase 1: structural foundation of substrate recognition, complex interactions and drug targeting
por: Rajappa-Titu, Lional, et al.
Publicado: (2016)

Magnesium-binding studies reveal fundamental differences between closely related RNA triphosphatases
por: Soulière, Marie F., et al.
Publicado: (2008)

Mechanisms of covalent self-assembly of the Azoarcus ribozyme from four fragment oligonucleotides
por: Draper, Will E., et al.
Publicado: (2008)

Cordycepin-hypersensitive growth links elevated polyphosphate levels to inhibition of poly(A) polymerase in Saccharomyces cerevisiae
por: Holbein, Sandra, et al.
Publicado: (2008)

The Leu22Pro tumor-associated variant of DNA polymerase beta is dRP lyase deficient
por: Dalal, Shibani, et al.
Publicado: (2008)

DNA polymerase kappa produces interrupted mutations and displays polar pausing within mononucleotide microsatellite sequences
por: Hile, Suzanne E., et al.
Publicado: (2008)

The N-terminal domain of TWINKLE contributes to single-stranded DNA binding and DNA helicase activities
por: Farge, Géraldine, et al.
Publicado: (2008)

The yeast ribosome synthesis factor Emg1 is a novel member of the superfamily of alpha/beta knot fold methyltransferases
por: Leulliot, Nicolas, et al.
Publicado: (2008)

Structure–function analysis of the RNA polymerase cleft loops elucidates initial transcription, DNA unwinding and RNA displacement
por: Naji, Souad, et al.
Publicado: (2008)

Site specific phosphorylation of yeast RNA polymerase I
por: Gerber, Jochen, et al.
Publicado: (2008)

HU binds and folds single-stranded DNA
por: Kamashev, Dmitri, et al.
Publicado: (2008)

Uracil recognition by replicative DNA polymerases is limited to the archaea, not occurring with bacteria and eukarya
por: Wardle, Josephine, et al.
Publicado: (2008)

Identification and characterization of coumestans as novel HCV NS5B polymerase inhibitors
por: Kaushik-Basu, Neerja, et al.
Publicado: (2008)

Substitution of a residue contacting the triphosphate moiety of the incoming nucleotide increases the fidelity of yeast DNA polymerase ζ
por: Howell, Craig A., et al.
Publicado: (2008)

EXOG, a novel paralog of Endonuclease G in higher eukaryotes
por: Cymerman, Iwona A., et al.
Publicado: (2008)

Multiple DNA-binding sites in Tetrahymena telomerase
por: Finger, Sharon N., et al.
Publicado: (2008)

Characterization and evolutionary history of an archaeal kinase involved in selenocysteinyl-tRNA formation
por: Sherrer, R. Lynn, et al.
Publicado: (2008)

Coupling of DNA binding and helicase activity is mediated by a conserved loop in the MCM protein
por: Sakakibara, Nozomi, et al.
Publicado: (2008)

The RNA polymerase factory: a robotic in vitro assembly platform for high-throughput production of recombinant protein complexes
por: Nottebaum, Sven, et al.
Publicado: (2008)

Identification of functional domains in Arabidopsis thaliana mRNA decapping enzyme (AtDcp2)
por: Gunawardana, Dilantha, et al.
Publicado: (2008)

Mutation of the arginine finger in the active site of Escherichia coli DbpA abolishes ATPase and helicase activity and confers a dominant slow growth phenotype
por: Elles, Lisa M. Sharpe, et al.
Publicado: (2008)

Cell type differences in activity of the Streptomyces bacteriophage ϕC31 integrase
por: Maucksch, Christof, et al.
Publicado: (2008)

Evidence for an inositol hexakisphosphate-dependent role for Ku in mammalian nonhomologous end joining that is independent of its role in the DNA-dependent protein kinase
por: Cheung, Joyce C.Y., et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_80qo1jp7u8q1q0cujp984g5pho