Phosphorylation and ubiquitination-dependent degradation of CABIN1 releases p53 for transactivation upon genotoxic stress

CABIN1 acts as a negative regulator of p53 by keeping p53 in an inactive state on chromatin. Genotoxic stress causes rapid dissociation of CABIN1 and activation of p53. However, its molecular mechanism is still unknown. Here, we reveal the phosphorylation- and ubiquitination-dependent degradation of...

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Detalles Bibliográficos
Autores principales: Choi, Soo-Youn, Jang, Hyonchol, Roe, Jae-Seok, Kim, Seong-Tae, Cho, Eun-Jung, Youn, Hong-Duk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575827/
https://www.ncbi.nlm.nih.gov/pubmed/23303793
http://dx.doi.org/10.1093/nar/gks1319

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575827/
https://www.ncbi.nlm.nih.gov/pubmed/23303793
http://dx.doi.org/10.1093/nar/gks1319

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