Circularized synthetic oligodeoxynucleotides serve as promoterless RNA polymerase III templates for small RNA generation in human cells

Synthetic RNA formulations and viral vectors are the two main approaches for delivering small therapeutic RNA to human cells. Here we report findings supporting an alternative strategy in which an endogenous human RNA polymerase (RNAP) is harnessed to make RNA hairpin-containing small RNA from synth...

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Detalles Bibliográficos
Autores principales: Seidl, Christine I., Lama, Lodoe, Ryan, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575851/
https://www.ncbi.nlm.nih.gov/pubmed/23275570
http://dx.doi.org/10.1093/nar/gks1334

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575851/
https://www.ncbi.nlm.nih.gov/pubmed/23275570
http://dx.doi.org/10.1093/nar/gks1334

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