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Influence of DNA Repair on Nonlinear Dose-Responses for Mutation

Recent evidence has challenged the default assumption that all DNA-reactive alkylating agents exhibit a linear dose-response. Emerging evidence suggests that the model alkylating agents methyl- and ethylmethanesulfonate and methylnitrosourea (MNU) and ethylnitrosourea observe a nonlinear dose-respon...

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Detalles Bibliográficos
Autores principales:	Thomas, Adam D., Jenkins, Gareth J. S., Kaina, Bernd, Bodger, Owen G., Tomaszowski, Karl-Heinz, Lewis, Paul D., Doak, Shareen H., Johnson, George E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576011/ https://www.ncbi.nlm.nih.gov/pubmed/23288051 http://dx.doi.org/10.1093/toxsci/kfs341

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