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The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model

BACKGROUND: Acetaminophen (N-acetyl-para-aminophenol) is the most widely used over-the-counter or prescription painkiller in the world. Acetaminophen is metabolized in the liver where a toxic byproduct is produced that can be removed by conjugation with glutathione. Acetaminophen overdoses, either a...

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Detalles Bibliográficos
Autores principales:	Ben-Shachar, Rotem, Chen, Yifei, Luo, Shishi, Hartman, Catherine, Reed, Michael, Nijhout, H Frederik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576299/ https://www.ncbi.nlm.nih.gov/pubmed/23249634 http://dx.doi.org/10.1186/1742-4682-9-55

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