A Force-Activated Trip Switch Triggers Rapid Dissociation of a Colicin from Its Immunity Protein

Colicins are protein antibiotics synthesised by Escherichia coli strains to target and kill related bacteria. To prevent host suicide, colicins are inactivated by binding to immunity proteins. Despite their high avidity (K(d)≈fM, lifetime ≈4 days), immunity protein release is a pre-requisite of coli...

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Detalles Bibliográficos
Autores principales: Farrance, Oliver E., Hann, Eleanore, Kaminska, Renata, Housden, Nicholas G., Derrington, Sasha R., Kleanthous, Colin, Radford, Sheena E., Brockwell, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576412/
https://www.ncbi.nlm.nih.gov/pubmed/23431269
http://dx.doi.org/10.1371/journal.pbio.1001489

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576412/
https://www.ncbi.nlm.nih.gov/pubmed/23431269
http://dx.doi.org/10.1371/journal.pbio.1001489

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