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A Force-Activated Trip Switch Triggers Rapid Dissociation of a Colicin from Its Immunity Protein
Colicins are protein antibiotics synthesised by Escherichia coli strains to target and kill related bacteria. To prevent host suicide, colicins are inactivated by binding to immunity proteins. Despite their high avidity (K(d)≈fM, lifetime ≈4 days), immunity protein release is a pre-requisite of coli...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576412/ https://www.ncbi.nlm.nih.gov/pubmed/23431269 http://dx.doi.org/10.1371/journal.pbio.1001489 |