UNC93B1 mediates differential trafficking of endosomal TLRs

UNC93B1, a multipass transmembrane protein required for TLR3, TLR7, TLR9, TLR11, TLR12, and TLR13 function, controls trafficking of TLRs from the endoplasmic reticulum (ER) to endolysosomes. The mechanisms by which UNC93B1 mediates these regulatory effects remain unclear. Here, we demonstrate that U...

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Detalles Bibliográficos
Autores principales: Lee, Bettina L, Moon, Joanne E, Shu, Jeffrey H, Yuan, Lin, Newman, Zachary R, Schekman, Randy, Barton, Gregory M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2013
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576711/
https://www.ncbi.nlm.nih.gov/pubmed/23426999
http://dx.doi.org/10.7554/eLife.00291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576711/
https://www.ncbi.nlm.nih.gov/pubmed/23426999
http://dx.doi.org/10.7554/eLife.00291

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