Osteocalcin Induces Release of Glucagon-Like Peptide-1 and Thereby Stimulates Insulin Secretion in Mice

The uncarboxylated form (ucOC), but not the γ-carboxylated form (GlaOC), of the bone-derived protein osteocalcin stimulates insulin secretion and regulates energy metabolism in insulin target tissues. Glucagon-like peptide–1 (GLP-1) is an insulin secretagogue that is released from the gut in respons...

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Detalles Bibliográficos
Autores principales: Mizokami, Akiko, Yasutake, Yu, Gao, Jing, Matsuda, Miho, Takahashi, Ichiro, Takeuchi, Hiroshi, Hirata, Masato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577726/
https://www.ncbi.nlm.nih.gov/pubmed/23437377
http://dx.doi.org/10.1371/journal.pone.0057375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577726/
https://www.ncbi.nlm.nih.gov/pubmed/23437377
http://dx.doi.org/10.1371/journal.pone.0057375

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