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p62/SQSTM1 Enhances NOD2-Mediated Signaling and Cytokine Production through Stabilizing NOD2 Oligomerization

NOD2 is a cytosolic pattern-recognition receptor that senses muramyl dipeptide of peptidoglycan that constitutes the bacterial cell wall, and plays an important role in maintaining immunological homeostasis in the intestine. To date, multiple molecules have shown to be involved in regulating NOD2 si...

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Detalles Bibliográficos
Autores principales: Park, Sangwook, Ha, Soon-Duck, Coleman, Macon, Meshkibaf, Shahab, Kim, Sung Ouk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577775/
https://www.ncbi.nlm.nih.gov/pubmed/23437331
http://dx.doi.org/10.1371/journal.pone.0057138