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Leishmania major Methionine Sulfoxide Reductase A Is Required for Resistance to Oxidative Stress and Efficient Replication in Macrophages

Leishmania are protozoan parasites that proliferate within the phagolysome of mammalian macrophages. While a number of anti-oxidant systems in these parasites have been shown to protect against endogenous as well as host-generated reactive oxygen species, the potential role of enzymes involved in th...

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Detalles Bibliográficos
Autores principales: Sansom, Fiona M., Tang, Leonie, Ralton, Julie E., Saunders, Eleanor C., Naderer, Thomas, McConville, Malcolm J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577802/
https://www.ncbi.nlm.nih.gov/pubmed/23437085
http://dx.doi.org/10.1371/journal.pone.0056064