A Multiple Reaction Monitoring (MRM) Method to Detect Bcr-Abl Kinase Activity in CML Using a Peptide Biosensor

The protein kinase Bcr-Abl plays a major role in the pathogenesis of chronic myelogenous leukemia (CML), and is the target of the breakthrough drug imatinib (Gleevec™). While most patients respond well to imatinib, approximately 30% never achieve remission or develop resistance within 1–5 years of s...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Tzu-Yi, Eissler, Christie L., Hall, Mark C., Parker, Laurie L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577862/
https://www.ncbi.nlm.nih.gov/pubmed/23437189
http://dx.doi.org/10.1371/journal.pone.0056627

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577862/
https://www.ncbi.nlm.nih.gov/pubmed/23437189
http://dx.doi.org/10.1371/journal.pone.0056627

Ejemplares similares