Imatinib Ameliorates Neuroinflammation in a Rat Model of Multiple Sclerosis by Enhancing Blood-Brain Barrier Integrity and by Modulating the Peripheral Immune Response

Central nervous system (CNS) disorders such as ischemic stroke, multiple sclerosis (MS) or Alzheimeŕs disease are characterized by the loss of blood-brain barrier (BBB) integrity. Here we demonstrate that the small tyrosine kinase inhibitor imatinib enhances BBB integrity in experimental autoimmune...

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Detalles Bibliográficos
Autores principales: Z. Adzemovic, Milena, Zeitelhofer, Manuel, Eriksson, Ulf, Olsson, Tomas, Nilsson, Ingrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577871/
https://www.ncbi.nlm.nih.gov/pubmed/23437178
http://dx.doi.org/10.1371/journal.pone.0056586

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577871/
https://www.ncbi.nlm.nih.gov/pubmed/23437178
http://dx.doi.org/10.1371/journal.pone.0056586

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