An Integrated Expression Profiling Reveals Target Genes of TGF-β and TNF-α Possibly Mediated by MicroRNAs in Lung Cancer Cells

EMT (epithelial-mesenchymal transition) is crucial for cancer cells to acquire invasive phenotypes. In A549 lung adenocarcinoma cells, TGF-β elicited EMT in Smad-dependent manner and TNF-α accelerated this process, as confirmed by cell morphology, expression of EMT markers, capacity of gelatin lysis...

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Detalles Bibliográficos
Autores principales: Saito, Akira, Suzuki, Hiroshi I., Horie, Masafumi, Ohshima, Mitsuhiro, Morishita, Yasuyuki, Abiko, Yoshimitsu, Nagase, Takahide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577886/
https://www.ncbi.nlm.nih.gov/pubmed/23437179
http://dx.doi.org/10.1371/journal.pone.0056587

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577886/
https://www.ncbi.nlm.nih.gov/pubmed/23437179
http://dx.doi.org/10.1371/journal.pone.0056587

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